Centre d'Immunophénomique (CIPHE)

The CIPHE is dedicated to the construction and phenotyping of mice of interest for Immunology and Infectiology. Through a series of almost 200 quantitative parameters, CIPHE has the unique ability to phenotype all the cellular components of the immune system under normal conditions or when confronted with pathogens. Moreover, the CIPHE is currently involved in the construction of a public resource comprised of nearly 50 knock-in mice to provide new informations on the nature of "molecular machines" determining the behavior of immune cells.

  • Creation of models (Knock-In - Knock-Out booster)
  • Microinjection and cryopreservation
  • Immunophenotyping (over 200 quantitative parameters)
  • Producing, housing and breeding mice in SOPF facility; housing and immunophenotyping in BSL3 facility

  • European Advanced School for Mouse Phenogenomics
    June 8-12, 2015, in the North of Alsace
    Courses are given in English.
    PHENOMIN (which gathers iCS, CIPHE & TAAM) offers an international and first class training to provide engineers (Master’s degrees), PhDs and researchers with a wealth of information about the good practices regarding the use of mouse models in biomedical research. The topics of mouse genetics, mutagenesis, phenotyping, mouse colony management, conservation and distribution of genetically modified mice will be covered. It's a unique opportunity to share knowledge and transfer new concepts and innovative methods.
    37 experts, whose European speakers involved in INFRAFRONTIER Mouse clinics, will share with you all the new approaches that will profoundly change the basic, preclinical and biopharmaceuticals researches.

    Objectives of the courses:
    ① Accelerate the sharing of conceptual scientific advances, and all the new approaches that will profoundly change the basic research, preclinical and biopharmaceuticals discoveries.
    ② Transfer of technological knowledge ensuring the most effective experimental procedures in compliance with ethics and animal welfare for a successful use of mouse models.
    ③ Support attendees in use of European and international resources for mouse phenogenomics (cryopreservation, distribution and phenotyping data lines already characterized and available to the scientific community).
    ④ Help and advice attendees in their own research project through poster session, relevant work session on scientific and methodological issues, oral retransmission and personalized discussion with experts.
    ⑤ Address the issue of continuing professional education consistent with the new European directive requirements about regulatory training and lab animal experiments.
    ▪ June 8-12, 2015, Liebfrauenberg Castle, Goersdorf, (North of Alsace)
    Training program

CIPHE has developed several R&D activities that permitted to maintain a constellation of innovative and branded new technologies in genetic engineering of the mouse genome, immunology and infectiology. A few of those activities are outlined below:

Genome editing

  • Gene engineering tools (‘’One-StrepTagged’’ alleles for interactomics of primary immunocytes, cassette allowing the fast-track construction of multitask alleles, multicolor mice)
  • Gene editing technology tools (TALE nucleases, CRISPR/Cas9)



  • Reporter mouse lines for the study of the innate and adaptive immune systems
  • Immunophenotyping panels and assays under normal or infectious (BSL3) conditions (unique combination of antibodies, fluorochromes and user-friendly analysis of data)

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