Simian Laboratory Europe (SILABE)

Located at Fort Foch in Niederhausbergen, SILABE is a service platform of the University of Strasbourg dedicated to supporting scientific research in the field of Non-Human Primate (NHP). Since its creation in 1978, this structure has been dedicated to the behavioural study of NHPs raised in social groups and to the preservation of the species. Today, its expertise enables it to offer a range of services to academic research institutions and industries in the health sector: housing, quarantine, supply of animals, biological sampling, pre-clinical scientific studies, training and advice.

The AAALAC-accredited site houses nine NHP species in infrastructures that meet European standards and offer an optimal environment in terms of animal welfare. These species represent the 3 main families of NHP: Prosimians (brown and black lemurs), Old World Primates (cynomolgus macaques, rhesus macaques, Tonkean macaques and vervets) and New World Primates (marmosets, brown capuchins and monk capuchins).

SILABE is involved in many scientific networks: SFDP, EPV, GIRCOR, FELASA, BIOSIMIA, AFSTAL, PRIMTRAIN, EFP, with the aim of sharing, strengthening and developing its knowledge and expertise in fields related to the NHP.

Since 2011, SILABE has been ISO 9001 certified and has a quality management system enabling it to structure its activities in compliance with the regulations in force.

Hosting and supply of non-human primates

  • Production, hosting and supply of non-human primates (NHP)
  • Management of NHP import and quarantine
  • Health monitoring and animal welfare

Biological sampling

  • Supply of biological samples (blood, plasma, serum, bone marrow, cerebrospinal fluid, vitreous humour, aqueous humour, urine, hair, faeces...)

Customised studies

  • In vivo studies:
    ◊ surgery
    ◊ clinical biology
    ◊ histology / histochemistry
    ◊ imaging
    ◊ ophtalmology
    ◊ reproduction
  • Preclinical exploratory studies for health industries

Trainings in primatology

  • Pain management
  • Use of primates in biomedical research
  • Management of behaviour, environment and stress of primates in captivity

Trainings specific to non-human primates

All trainings are made in collaboration with the Center of Primatology and the service of continuing education of Strasbourg University. SILABE proposes trainings dedicated to staff working with non-human primates (NHP).

  • Pain management of the primates
    This module focuses on the comprehension of pain and suffering of primates kept in captivity for scientific purposes and their reduction. It responds the regulatory requirements of continuing education according article 5 of the French Ministerial Decree of 01/02/13 in respect of the acquisition and validation of staff expertise in user establishments, breeders and suppliers of animals used on a scientific purpose.
    This training is intended for researchers, vets, zootechnicians, ethical committee members, welfare structures members and generally speaking for all users of primates in the fields of biomedical research.
    After completion, the trainee will be able to express the concept of pain in physiological terms, to identify the signs of pain, to evaluate the degrees of severity, to define the endpoints, to implement solutions and protocols for pain treatment.
    Topics are:
    ① Physiological mechanisms of the pain
    ② Recognition of the signs of stress, distress, pain and suffering specific to primates
    ③ Use of adapted endpoints
    ④ Management of the pain, its prevention, medical and environmental treatments
    ⑤ Anesthetic and analgesic protocols
    ⑥ Methods of euthanasia
    Training in collaboration with the University of Strasbourg: 3 days
    ▪ Session in Niederhausbergen (outskirts of Strasbourg) in 2020: June 8-10
    Description
  • The primate in biomedical research
    Training intended for researchers, vets, zootechnicians, and generally speaking for all users of primates in the fields of biomedical research.
    Aims off the training:
    ① To address the non-human primate model in research according the new European recommendations and according the project
    ② To better understand physiological and behavioural needs, NHP diseases, for a better management of their health and welfare in animal facilities
    ③ To detect the signs of stress, distress and pain and to implement appropriate solutions
    ④ To analyse NHP with exploratory technics in the respect of 3R rules
    Training in collaboration with the University of Strasbourg: 5 days
    ▪ Session in Niederhausbergen (outskirts of Strasbourg) in 2019: November 4-8
    Description

 

  • Managing behaviour, environment and stress of non-human primates in captivity
    Training intended for researchers, vets, animal facilities managers, zootechnicians, and generally speaking for all users of primates kept in captivity.
    The aim is to acquire tools to optimise the welfare of NHP kept in captivity, through the management of their environment and a better understanding of their behaviour and needs.

    This training is shared in three  workshops which can be attended separately :
    ① Management of the behaviour of primates in captivity : feeding, social organisation, dominance hierarchy, impact of captivity, ethology, tools to measure and understand their behaviour and their use to reduce stress during handling and to train primates to cooperate
    ② management of the environment of primates in captivity: social environment, physical environment, Gestion de l'environnement des primates en captivité : environnement social, environnement physique, enrichment of the environment
    ③ Management of the stress of primates in captivity : questions on stress, its origins, its measurements, its prevention, its identification, the resolution of behavioural problems, implementation of corrective actions
    Training in collaboration with the University of Strasbourg: 3 days
    ▪ Session in Niederhausbergen (outskirts of Strasbourg) in 2020: from March 31 to April 2 (Possible to attend 1 or 2 workshops out of 3)
    Description

 

  • The marmoset (Callithrix jacchus) in biomedical research
    The program of that training intended for researchers, vets, zootechnicians, and generally speaking for all users of primates in the fields of biomedical research, can be adapted to the demand.
    Aims of the training
    ① To be aware of the behavioral and biological characteristics (anatomy, physiology, immunology, reproduction ...) of marmosets.
    ② To learn procedures adapted to hosting, husbandry, feeding, care and health status of marmosets.
    ③ To get familiar with the techniques of handling and investigation in an experimental context.
    ④ To understand how to use marmoset model in research by a good knowledge of its peculiarities
    Training in collaboration with the University of Strasbourg
    ▪ Training on demand, Niederhausbergen (outskirts of Strasbourg)

Contribution to regulatory trainings

The objective is to acquire the mandatory qualification to practice animal experimentation in accordance with the transposition of the new European Directive 2010/63.

  • Regulatory training session in ENGLISH for staff developing experimental procedures and projects on "rodents" organized by CE2F-PRIM and CELPHEDIA
    Training limited to non-Francophone students and researchers working in a CNRS unit: 7 days
    ▪ 1 session in Strasbourg in 2019: October 10-18
    Registration procedures

Customised trainings

  • SILABE organises customised trainings on demand

Hosting of students

  • SILABE welcomes, under convention, students with various curriculum

Zootechny

  • Nutrition
  • Reproduction
  • Enrichment
  • Training of primates to cooperate

Functional exploration of non-human primates

  • Behavioural assays on groups living in semi-wild areas
  • Development of exploratory tools for primates (telemetry, imaging, neurocognition assays, videotracking).
  • Comparative testing by software on aging

Metabolic diseases

  • Creation of NHP models for drug testings in collaboration with the University of Strasbourg
  • Natural observations of obesity and molecular assays

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